Delayed Degradation and Impaired Dendritic Delivery of Intron-Lacking EGFP-Arc/Arg3.1 mRNA in EGFP-Arc Transgenic Mice

Arc is a unique immediate early gene (IEG) whose expression is induced as synapses are modified during learning. Newly-synthesized Arc mRNA is rapidly transported throughout dendrites and localizes near recently activated synapses. Arc mRNA levels are regulated by rapid degradation, which is acceler...

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Hlavní autoři:	Oswald Steward, Kelly Matsudaira Yee, Shannon Farris, Patricia S. Pirbhoy, Paul Worley, Kohji Okamura, Hiroyuki Okuno, Haruhiko Bito
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2018-01-01
Edice:	Frontiers in Molecular Neuroscience
Témata:	LTP synaptic plasticity protein synthesis dendrite dendritic mRNA dendritic spines
On-line přístup:	http://journal.frontiersin.org/article/10.3389/fnmol.2017.00435/full
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