Mitochondrial protective effects caused by the administration of mefenamic acid in sepsis
Abstract The pathophysiology of sepsis may involve the activation of the NOD-type receptor containing the pyrin-3 domain (NLPR-3), mitochondrial and oxidative damages. One of the primary essential oxidation products is 8-oxoguanine (8-oxoG), and its accumulation in mitochondrial DNA (mtDNA) induces...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BMC
2022-11-01
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| Schriftenreihe: | Journal of Neuroinflammation |
| Schlagworte: | |
| Online-Zugang: | https://doi.org/10.1186/s12974-022-02616-6 |
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