Complementary gene regulation by NRF1 and NRF2 protects against hepatic cholesterol overload

Summary: Hepatic cholesterol overload promotes steatohepatitis. Insufficient understanding of liver stress defense impedes therapy development. Here, we elucidate the role of stress defense transcription factors, nuclear factor erythroid 2 related factor-1 (NRF1) and -2 (NRF2), in counteracting chol...

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Bibliographic Details

Main Authors:	May G. Akl, Lei Li, Raquel Baccetto, Sadhna Phanse, Qingzhou Zhang, Michael J. Trites, Sherin McDonald, Hiroyuki Aoki, Mohan Babu, Scott B. Widenmaier
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2023-04-01
Series:	Cell Reports
Subjects:	CP: Metabolism
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124723004102
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