Pharmacological FGF21 signals to glutamatergic neurons to enhance leptin action and lower body weight during obesity

Objective: Fibroblast growth factor 21 (FGF21) is a peripherally-derived endocrine hormone that acts on the central nervous system (CNS) to regulate whole body energy homeostasis. Pharmacological administration of FGF21 promotes weight loss in obese animal models and human subjects with obesity. How...

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Autors principals:	Kristin E. Claflin, Andrew I. Sullivan, Meghan C. Naber, Kyle H. Flippo, Donald A. Morgan, Tate J. Neff, Sharon O. Jensen-Cody, Zhiyong Zhu, Leonid V. Zingman, Kamal Rahmouni, Matthew J. Potthoff
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2022-10-01
Col·lecció:	Molecular Metabolism
Matèries:	Neurons FGF21 Betaklotho Glutamatergic Leptin Adipose
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2212877822001338
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