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Exome Sequencing Reveals Signal Transduction Genes Involved in Impulse Control Disorders in Parkinson's Disease

Introduction: Impulse control disorders (ICDs) frequently complicate dopamine agonist (DA) therapy in Parkinson's disease (PD). There is growing evidence of a high heritability for ICDs in the general population and in PD. Variants on genes belonging to the reward pathway have been shown to account...

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Furkejuvvon:
Váldodahkkit: Sabine Prud'hon, Samir Bekadar, Agnès Rastetter, Justine Guégan, Florence Cormier-Dequaire, Lucette Lacomblez, Graziella Mangone, Hana You, Mailys Daniau, Yannick Marie, Hélène Bertrand, Suzanne Lesage, Sophie Tezenas Du Montcel, Mathieu Anheim, Alexis Brice, Fabrice Danjou, Jean-Christophe Corvol
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Frontiers Media S.A. 2020-07-01
Ráidu:Frontiers in Neurology
Fáttát:
Parkinson's disease (PD)
dopamine agonists (DA)
impulse control disorders (ICD)
pharmacogenetics
exome sequencing
Liŋkkat:https://www.frontiersin.org/article/10.3389/fneur.2020.00641/full
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