Sleep Deprivation Activates a Conserved Lactate‐H3K18la‐RORα Axis Driving Neutrophilic Inflammation Across Species

Abstract Sleep deprivation critically disrupts physiological homeostasis, impairing development, metabolic balance, and immune regulation, with excessive neutrophil activation being a hallmark consequence. However, the molecular mechanisms underlying sleep deprivation‐induced neutrophilic inflammati...

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Autori principali:	Ren Zhou, Keyun Li, Xiezong Hu, Shuhao Fan, Yuxuan Gao, Xiaoshu Xue, Yu Bu, Haoyi Zhang, Yili Wang, Chunjiao Wei, Shangrong Zhang, Zhongwen Xie, Chao Liu, Peng Chen, Zongjun Yin, Dalong Ren
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2025-10-01
Serie:	Advanced Science
Soggetti:	inflammation lactylation neutrophil Rorα sleep deprivation
Accesso online:	https://doi.org/10.1002/advs.202504028
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