IGF2BP3 recognizes m6A to regulate histone-to-protamine replacement during mouse sperm development

Abstract Post-meiotic development of spermatids is under the control of a sophisticated RNA metabolic network, wherein the N6-methyladenosine (m6A) modification of mRNA, and proteins that bind to it, exert crucial functions in regulating sperm development from spermatogonia to spermatocytes. However...

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Hlavní autoři:	Dazhuang Wang, Zhenyi Huang, Yichun Zhou, Peiyan Chen, Gang Chang, Liwei Ke, Congying Jing, Haojie Yang, Jiexiang Zhao, Shaofang Ren, Yi Zheng, Yuhan Chen, Yunfan Xiang, Jun Liu, Mei Wang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer Nature 2025-12-01
Edice:	The EMBO Journal
Témata:	IGF2BP3 m6A Reader Translation Inhibition Protamine Replacement Spermiogenesis
On-line přístup:	https://doi.org/10.1038/s44318-025-00659-y
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