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Neuropeptide deficient mice have attenuated nociceptive, vascular, and inflammatory changes in a tibia fracture model of complex regional pain syndrome

<p>Abstract</p> <p>Background</p> <p>Distal limb fracture in man can induce a complex regional pain syndrome (CRPS) with pain, warmth, edema, and cutaneous inflammation. In the present study substance P (SP, Tac1<sup>−/−</sup>) and CGRP receptor (RAMP1<sup>−/−</sup>) deficient mice were used to inve...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Guo Tian-Zhi, Wei Tzuping, Shi Xiaoyou, Li Wen-Wu, Hou Saiyun, Wang Liping, Tsujikawa Kazutake, Rice Kenner C, Cheng Kejun, Clark David J, Kingery Wade S
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE Publishing 2012-11-01
Schriftenreihe:Molecular Pain
Schlagworte:
Substance P
Calcitonin gene-related peptide
Fracture
Complex regional pain syndrome
Inflammation
Pain
Cytokine
Nerve growth factor
Online-Zugang:http://www.molecularpain.com/content/8/1/85
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