Creatine transporter (SLC6A8) knock out mice display an increased capacity for in vitro creatine biosynthesis in skeletal muscle

The present study aimed to investigate whether skeletal muscle from whole body creatine transporter (CrT; SLC6A8) knockout mice (CrT-/y) actually contained creatine (Cr) and if so, whether this Cr could result from an up regulation of muscle Cr biosynthesis. Gastrocnemius muscle from CrT-/y and wild...

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Autori principali:	Aaron Paul Russell, Lobna eGhobrial, Craig Robert Wright, Severine eLamon, Erin eBrown, Michihiro eKon, Matthew eSkelton, Rodney eSnow
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2014-08-01
Serie:	Frontiers in Physiology
Soggetti:	Creatine Energy Metabolism skeletal muscle Creatine transporter creatine synthesis
Accesso online:	http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00314/full
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