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HMGB1 inhibition reduces TDI-induced occupational asthma through ROS/AMPK/autophagy pathway

Exposure to toluene diisocyanate (TDI) can cause pulmonary diseases such as asthma. Inhibition of high mobility group box 1 protein (HMGB1) has been found to be protective against the toxic effects of TDI on human bronchial epithelial (HBE) cells. Here, we evaluated the in vivo positive roles of HMG...

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Hlavní autoři: Xiangjing Meng, Sumei Guo, Xiaoxia Zhang, Bo Jiao, Xiaohan Yang, Ming Li, Chao Li, Jin He, Shangya Chen, Cheng Peng, Hua Shao, Qiang Jia
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2023-11-01
Edice:Ecotoxicology and Environmental Safety
Témata:
Toluene diisocyanate
Asthma
High mobility group box 1
Airway inflammation
Autophagy
On-line přístup:http://www.sciencedirect.com/science/article/pii/S0147651323010795
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