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Translational Analysis of Moderate to Severe Asthma GWAS Signals Into Candidate Causal Genes and Their Functional, Tissue-Dependent and Disease-Related Associations

Asthma affects more than 300 million people globally and is both under diagnosed and under treated. The most recent and largest genome-wide association study investigating moderate to severe asthma to date was carried out in 2019 and identified 25 independent signals. However, as new and in-depth do...

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Principais autores: Michael A. Portelli, Kamini Rakkar, Sile Hu, Yike Guo, Ian M. Adcock
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-10-01
coleção:Frontiers in Allergy
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Acesso em linha:https://www.frontiersin.org/articles/10.3389/falgy.2021.738741/full
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