CRISPR-mediated base editing in mice using cytosine deaminase base editor 4

Background: Many human genetic diseases arise from point mutations. These genetic diseases can theoretically be corrected through gene therapy. However, gene therapy in clinical application is still far from mature. Nearly half of the pathogenic single-nucleotide polymorphisms (SNPs) are caused by G...

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Bibliografiske detaljer

Principais autores:	Salah Adlat, Farooq Hayel, Ping Yang, Yang Chen, Zin Mar Oo, May Zun Zaw Myint, Rajiv Kumar Sah, Noor Bahadar, Mahmoud Al-Azab, Fatoumata Binta Bah, Yaowu Zheng, Xuechao Feng
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2021-07-01
Serier:	Electronic Journal of Biotechnology
Fag:	Base editor 4 CRISPR-Cas9 Cytosine base editing Cytosine Deaminase Mouse model Single-base substitution
Online adgang:	http://www.sciencedirect.com/science/article/pii/S0717345821000257
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