Mitochondrial-Targeted Therapies Require Mitophagy to Prevent Oxidative Stress Induced by SOD2 Inactivation in Hypertrophied Cardiomyocytes

Heart failure, mostly associated with cardiac hypertrophy, is a major cause of illness and death. Oxidative stress causes accumulation of reactive oxygen species (ROS), leading to mitochondrial dysfunction, suggesting that mitochondria-targeted therapies could be effective in this context. The purpo...

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Hlavní autoři:	Victoriane Peugnet, Maggy Chwastyniak, Paul Mulder, Steve Lancel, Laurent Bultot, Natacha Fourny, Edith Renguet, Heiko Bugger, Olivia Beseme, Anne Loyens, Wilfried Heyse, Vincent Richard, Philippe Amouyel, Luc Bertrand, Florence Pinet, Emilie Dubois-Deruy
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2022-04-01
Edice:	Antioxidants
Témata:	oxidative stress mitochondrial dysfunction mitochondrial antioxidant superoxide dismutase 2 acetylation mitophagy
On-line přístup:	https://www.mdpi.com/2076-3921/11/4/723
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