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A validated generally applicable approach using the systematic assessment of disease modules by GWAS reveals a multi-omic module strongly associated with risk factors in multiple sclerosis

Abstract Background There exist few, if any, practical guidelines for predictive and falsifiable multi-omic data integration that systematically integrate existing knowledge. Disease modules are popular concepts for interpreting genome-wide studies in medicine but have so far not been systematically...

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Principais autores: Tejaswi V. S. Badam, Hendrik A. de Weerd, David Martínez-Enguita, Tomas Olsson, Lars Alfredsson, Ingrid Kockum, Maja Jagodic, Zelmina Lubovac-Pilav, Mika Gustafsson
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2021-08-01
Series:BMC Genomics
Assuntos:
Benchmark
Multi-omics
Network modules
Multiple sclerosis
Risk factors
Disease modules
Acceso en liña:https://doi.org/10.1186/s12864-021-07935-1
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