Targeted intracellular delivery of Cas13 and Cas9 nucleases using bacterial toxin-based platforms

Summary: Targeted delivery of therapeutic proteins toward specific cells and across cell membranes remains major challenges. Here, we develop protein-based delivery systems utilizing detoxified single-chain bacterial toxins such as diphtheria toxin (DT) and botulinum neurotoxin (BoNT)-like toxin, Bo...

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Autors principals:	Songhai Tian, Yang Liu, Evan Appleton, Huan Wang, George M. Church, Min Dong
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2022-03-01
Col·lecció:	Cell Reports
Matèries:	CRISPR-Cas9 Cas9 Cas13 Cre intracellular delivery toxin
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124722002091
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