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Rif1 inhibits replication fork progression and controls DNA copy number in Drosophila

Control of DNA copy number is essential to maintain genome stability and ensure proper cell and tissue function. In Drosophila polyploid cells, the SNF2-domain-containing SUUR protein inhibits replication fork progression within specific regions of the genome to promote DNA underreplication. While d...

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Principais autores: Alexander Munden, Zhan Rong, Amanda Sun, Rama Gangula, Simon Mallal, Jared T Nordman
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2018-10-01
coleção:eLife
Assuntos:
DNA replication
common fragile sites
replication timing
genome stability
under replication
polyploid
Acesso em linha:https://elifesciences.org/articles/39140
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