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Poloxamer-188 and <span style="font-variant: small-caps">d</span>-α-Tocopheryl Polyethylene Glycol Succinate (TPGS-1000) Mixed Micelles Integrated Orodispersible Sublingual Films to Improve Oral Bioavailability of Ebastine; In Vitro and In Vivo Characterization

Orodispersible sublingual films (OSFs) composed of hydrophilic polymers were loaded with poloxamer-188 and <span style="font-variant: small-caps;">d</span>-α-tocopheryl polyethylene glycol succinate (TPGS-1000) mixed micelles to improve the oral bioavailability of a poorly soluble drug, ebastine (EB...

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Principais autores: Nayyer Islam, Muhammad Irfan, Salah-Ud-Din Khan, Haroon Khalid Syed, Muhammad Shahid Iqbal, Ikram Ullah Khan, Amina Mahdy, Mohamed Raafat, Mohammad Akbar Hossain, Sana Inam, Rabia Munir, Memoona Ishtiaq
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-01-01
Serier:Pharmaceutics
Fag:
ebastine
poloxamer-188
<span style="font-variant: small-caps">d</span>-α-tocopheryl polyethylene glycol succinate
micelles
bioavailability
toxicity
Online adgang:https://www.mdpi.com/1999-4923/13/1/54
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