Indolent Systemic Mastocytosis Presenting with Consecutive Vertebral Fragility Fractures despite Normal Bone Mineral Density: A Case Report and Mechanistic Review

Introduction: Indolent systemic mastocytosis (ISM) is a rare clonal mast-cell disorder that may present with skeletal involvement, driven by mast-cell mediator–induced osteoclast activation. Vertebral fragility fractures can occur even in the presence of normal bone mineral density (BMD), making ear...

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Bibliographic Details

Main Authors:	Ratko Yurac Barrientos, Joaquín Zúñiga Soria, Andrea Marré Chadwick, Nicolás Bifani Toche
Format:	Artigo
Language:	Inglês
Published:	Indian Orthopaedic Research Group 2026-05-01
Series:	Journal of Orthopaedic Case Reports
Subjects:	indolent systemic mastocytosis vertebral fragility fractures secondary osteoporosis kit d816v mutation tryptase bone biopsy normal bone mineral density kyphoplasty biopsy mast cell–mediated bone loss
Online Access:	https://jocr.co.in/wp/2026/05/indolent-systemic-mastocytosis-presenting-with-consecutive-vertebral-fragility-fractures-despite-normal-bone-mineral-density-a-case-report-and-mechanistic-review/
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