Antibody:CD47 ratio regulates macrophage phagocytosis through competitive receptor phosphorylation

Summary: Cancer immunotherapies often modulate macrophage effector function by introducing either targeting antibodies that activate Fcγ receptors (FcγRs) or blocking antibodies that disrupt inhibitory SIRPα-CD47 engagement. However, how these competing signals are integrated is poorly understood, r...

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Hlavní autoři:	Emily C. Suter, Eva M. Schmid, Andrew R. Harris, Erik Voets, Brian Francica, Daniel A. Fletcher
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2021-08-01
Edice:	Cell Reports
Témata:	macrophage phagocytosis Fc receptor therapeutic antibody SIRPα CD47
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2211124721010214
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