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Chondrogenic differentiation of bone marrow-derived mesenchymal stem cells following transfection with Indian hedgehog and sonic hedgehog using a rotary cell culture system

Abstract Background Indian hedgehog (IHH) and Sonic hedgehog (SHH) are important regulators of chondrogenesis. However, activation of IHH and SHH also promotes chondrocyte hypertrophy and ossification during chondrogenesis. The aims of this study were to investigate the effect of microgravity on IHH...

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Principais autores: Liyang Chen, Gejun Liu, Wenjun Li, Xing Wu
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-02-01
Serier:Cellular & Molecular Biology Letters
Fag:
Indian hedgehog
Sonic hedgehog
RCCS
Chondrogenic differentiation
Chondrocyte hypertrophy
Online adgang:http://link.springer.com/article/10.1186/s11658-019-0144-2
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