A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase.

The TERT-CLPTM1L region of chromosome 5p15.33 is a multi-cancer susceptibility locus that encodes the reverse transcriptase subunit, hTERT, of the telomerase enzyme. Numerous cancer-associated single-nucleotide polymorphisms (SNPs), including rs10069690, have been identified within the hTERT gene. T...

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Principais autores:	Anagha Killedar, Michael D Stutz, Alexander P Sobinoff, Christopher G Tomlinson, Tracy M Bryan, Jonathan Beesley, Georgia Chenevix-Trench, Roger R Reddel, Hilda A Pickett
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2015-06-01
coleção:	PLoS Genetics
Acesso em linha:	http://europepmc.org/articles/PMC4459975?pdf=render
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