The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration

Abstract Kidney filtration is ensured by the interaction of podocytes, endothelial and mesangial cells. Immunoglobulin accumulation at the filtration barrier is pathognomonic for glomerular injury. The mechanisms that regulate filter permeability are unknown. Here, we identify a pivotal role for the...

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Detalhes bibliográficos

Principais autores:	Wiebke Sachs, Lukas Blume, Desiree Loreth, Lisa Schebsdat, Favian Hatje, Sybille Koehler, Uta Wedekind, Marlies Sachs, Stephanie Zieliniski, Johannes Brand, Christian Conze, Bogdan I. Florea, Frank Heppner, Elke Krüger, Markus M. Rinschen, Oliver Kretz, Roland Thünauer, Catherine Meyer-Schwesinger
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-03-01
Colecção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-024-46273-0
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