The novel orthosteric agonist M1 muscarinic acetylcholine receptor reveals anti-Alzheimer’s disease activity

Abstract Cholinergic treatments with an emphasis on M1 muscarinic acetylcholine receptor (mAChR) agonists as potential modulating agents are a new approach in Alzheimer’s disease (AD) therapy. In previous research, we designed and characterized novel thiazolidine-2,4-dione (TZD)-derived compounds th...

Description complète

Détails bibliographiques

Auteurs principaux:	Maryam Taheri, Maryam Afzali Mehr, Hossein Ghafouri
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2024-11-01
Collection:	Scientific Reports
Sujets:	Alzheimer’s disease (AD) Cholinergic pathway Agonist M1 muscarinic acetylcholine receptor Orthosteric site Thiazolidine-2,4-dione (TZD)
Accès en ligne:	https://doi.org/10.1038/s41598-024-80102-0
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!