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Recognition of yeast β-glucan particles triggers immunometabolic signaling required for trained immunity

Summary: Fungal β-glucans are major drivers of trained immunity which increases long-term protection against secondary infections. Heterogeneity in β-glucan source, structure, and solubility alters interaction with the phagocytic receptor Dectin-1 and could impact strategies to improve trained immun...

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Principais autores: Cian J.H. Horneck Johnston, Anna E. Ledwith, Mimmi L.E. Lundahl, Hugo Charles-Messance, Emer E. Hackett, Simon D. O’Shaughnessy, Jonah Clegg, Hannah Prendeville, John P. McGrath, Aaron M. Walsh, Sarah Case, Hollie Austen Byrne, Parth Gautam, Elaine Dempsey, Sinead C. Corr, Frederick J. Sheedy
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-03-01
coleção:iScience
Assuntos:
Physiology
Molecular biology
Immunology
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2589004224002517
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