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Profiling the peripheral immune response to ex vivo TNF stimulation in untreated juvenile idiopathic arthritis using single cell RNA sequencing

Abstract Background Juvenile Idiopathic Arthritis (JIA) is an autoimmune disease with a heterogenous clinical presentation and unpredictable response to available therapies. This personalized transcriptomics study sought proof-of-concept for single-cell RNA sequencing to characterize patient-specifi...

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Autori principali: Kathleen J. Imbach, Nicole J. Treadway, Vaishali Prahalad, Astrid Kosters, Dalia Arafat, Meixue Duan, Talia Gergely, Lori A. Ponder, Shanmuganathan Chandrakasan, Eliver E. B. Ghosn, Sampath Prahalad, Greg Gibson
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2023-02-01
Serie:Pediatric Rheumatology Online Journal
Soggetti:
JIA
Transcriptomics
Immunoprofiling
scRNAseq
Accesso online:https://doi.org/10.1186/s12969-023-00787-x
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