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Biopsy RNA-seq captures TROP-2–linked migration and clonal resistance to forecast aggressiveness in metastatic melanoma

Abstract Background Unlike many other solid tumors, melanoma cells possess a remarkable ability to dynamically transition between distinct transcriptional states in response to environmental cues or therapeutic pressure. Among the adaptive mechanisms underlying this plasticity, the epithelial-to-mes...

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Main Authors: Martina Betti, Celeste Accetta, Brindusa Ana Maria Arteni, Anya Rosselli, Elisa Melucci, Paolo Visca, Claudio Botti, Fabio Pelle, Michelangelo Russillo, Virginia Ferraresi, Emilia Migliano, Marianna Cerro, Stefano Scalera, Francesca De Nicola, Silvia Matteoni, Daniela Covino, Antonino Guerrisi, Matteo Pallocca, Maurizio Fanciulli, Edoardo Pescarmona, Giovanni Blandino, Rita Mancini, Italia Falcone, Simona Di Martino
Format: Artigo
Language:Inglês
Published: BMC 2026-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Metastatic melanoma
Dormancy
TROP2
RNA-seq
Cell lines
Biomarkers
Online Access:https://doi.org/10.1186/s13046-026-03646-1
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