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Knowledge-guided data mining on the standardized architecture of NRPS: Subtypes, novel motifs, and sequence entanglements.

Non-ribosomal peptide synthetase (NRPS) is a diverse family of biosynthetic enzymes for the assembly of bioactive peptides. Despite advances in microbial sequencing, the lack of a consistent standard for annotating NRPS domains and modules has made data-driven discoveries challenging. To address thi...

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Autori principali: Ruolin He, Jinyu Zhang, Yuanzhe Shao, Shaohua Gu, Chen Song, Long Qian, Wen-Bing Yin, Zhiyuan Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2023-05-01
Serie:PLoS Computational Biology
Accesso online:https://doi.org/10.1371/journal.pcbi.1011100
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