Immunometabolic regulation in gouty arthritis: current evidence, mechanistic insights, and remaining challenges

Gouty arthritis is driven by monosodium urate (MSU) crystal deposition and acute activation of the NLRP3 inflammasome–IL-1β axis. However, crystal burden alone does not fully explain asymptomatic crystal deposition, recurrent flares, or the self-limiting nature of acute inflammation. Immunometabolis...

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Detalhes bibliográficos

Principais autores:	Xingzheng Liu, Xingrui Yan, Tao Wang, TingTing Luo, Shengqin Yang, Yixin Fang, Xiumin Chen, Runyue Huang, Maojie Wang, Xiaodong Wu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-07-01
coleção:	Frontiers in Immunology
Assuntos:	gouty arthritis immunometabolism macrophages neutrophils NLRP3 inflammasome
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1795337/full
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