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CD8+CD161+ T-Cells: Cytotoxic Memory Cells With High Therapeutic Potential

NK1.1 and its human homolog CD161 are expressed on NK cells, subsets of CD4+ and CD8+ T cells, and NKT cells. While the expression of NK1.1 is thought to be inhibitory to NK cell function, it is reported to play both costimulatory and coinhibitory roles in T-cells. CD161 has been extensively studied...

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Autori principali: Vanaja Konduri, Damilola Oyewole-Said, Jonathan Vazquez-Perez, Scott A. Weldon, Matthew M. Halpert, Jonathan M. Levitt, William K. Decker
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021-02-01
Serie:Frontiers in Immunology
Soggetti:
KLRB1
CD161
effector memory
T-cell
TH1 polarization
Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2020.613204/full
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