Protease-activated receptor-2 promotes osteogenesis in skeletal mesenchymal stem cells at the expense of adipogenesis: Involvement of interleukin-6

Bone marrow mesenchymal stem cells (MSCs) give rise to osteoblasts and adipocytes, with an inverse relationship between the two. The MSCs from protease-activated receptor-2 knockout (PAR2 KO) mice have a reduced capacity to generate osteoblasts. Here we describe the observation that PAR2 KO osteobla...

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Auteurs principaux:	R. Sanaei, P.K. Kularathna, N. Taghavi, J.D. Hooper, C.N. Pagel, E.J. Mackie
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2021-12-01
Collection:	Bone Reports
Sujets:	Protease-activated receptor-2 Lineage determination Osteoblast Adipogenesis Interleukin-6 Mesenchymal stem cells
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2352187221003697
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