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Genetic profiling of patients with atopic dermatitis reveals immune and skin barrier variants associated with generalized eczema and optimal response to Dupilumab therapy

BackgroundAtopic dermatitis (AD) is a clinically heterogeneous immune-mediated skin disorder. The lack of reliable clinical stratification tools and predictive biomarkers for therapeutic response remains a critical unmet need to optimize treatment and advance precision dermatology.ObjectiveTo invest...

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Principais autores: Martina Morelli, Giovanni Luca Scaglione, Anna Dattolo, Marco Galluzzo, Claudia Scarponi, Gaia Moretta, Alessia Provini, Filomena Russo, Barbara Cocuroccia, Donatella Sordi, Marina Talamonti, Valeria Villella, Fabio Romano Selvi, Laura Mercurio, Claudia Paganini, Edoardo Mortato, Luca Bianchi, Ornella De Pità, Sabatino Pallotta, Enrico Scala, Cristina Albanesi, Stefania Madonna
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-04-01
Serier:Frontiers in Immunology
Fag:
atopic dermatitis
dupilumab
filaggrin
generalized eczema
KIF3A
pharmacogenomics
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1788831/full
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