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Inhibition of <i>PKCθ</i> Abrogates CD8<sup>+</sup> T Cell-Mediated Neurotoxicity in Murine Cerebral Malaria

<b>Background</b>: Cerebral malaria (CM) is a severe and often fatal complication of <i>Plasmodium falciparum</i> infection that causes devastating brain injury largely through immune-mediated mechanisms. Pathogenic brain-infiltrating CD8<sup>+</sup> T cells are key drivers of CM pathology, yet the...

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I tiakina i:
Ngā kaituhi matua: Karin Albrecht-Schgör, Victoria E. Stefan, Martina Steinlechner, Dominik Humer, Kerstin Siegmund, Sebastian Peer, Thomas Gruber, Maja Überegger, Stephanie zur Nedden, Gabriele Baier-Bitterlich, Peter Lackner, Erich Schmutzhard, Nikolaus Thuille, Victoria Klepsch, Gottfried Baier
Hōputu: Artigo
Reo:Inglês
I whakaputaina: MDPI AG 2025-10-01
Rangatū:Biomedicines
Ngā marau:
cerebral malaria (CM)
experimental cerebral malaria (ECM)
CD8<sup>+</sup> T cells
protein kinase C-θ (PKCθ)
neurovascular damage
immune-mediated brain injury
Urunga tuihono:https://www.mdpi.com/2227-9059/13/11/2582
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