A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse

In congenital stationary night blindness, type 2 (CSNB2)—a disorder involving the Cav1.4 (L-type) Ca2+ channel—visual impairment is mild considering that Cav1.4 mediates synaptic release from rod and cone photoreceptors. Here, we addressed this conundrum using a Cav1.4 knockout (KO) mouse and a knoc...

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Detalhes bibliográficos

Principais autores:	J Wesley Maddox, Gregory J Ordemann, Juan AM de la Rosa Vázquez, Angie Huang, Christof Gault, Serena R Wisner, Kate Randall, Daiki Futagi, Nihal A Salem, Dayne Mayfield, Boris V Zemelman, Steven DeVries, Mrinalini Hoon, Amy Lee
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2024-11-01
coleção:	eLife
Assuntos:	ictidomys tridecemlineatus calcium photoreceptor synapse retina
Acesso em linha:	https://elifesciences.org/articles/94908
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