Expression of a specific variant surface glycoprotein has a major impact on suramin sensitivity and endocytosis in Trypanosoma brucei

Abstract Suramin was introduced into the clinic a century ago and is still used to treat the first stage of acute human sleeping sickness. Due to its size and sixfold negative charge, uptake is mediated through endocytosis and the suramin receptor in trypanosomes is thought to be the invariant surfa...

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Ngā kaituhi matua:	Natalie Wiedemar, Michaela Zwyer, Martin Zoltner, Monica Cal, Mark C. Field, Pascal Mäser
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Wiley 2019-10-01
Rangatū:	FASEB BioAdvances
Ngā marau:	drug resistance human African trypanosomiasis low‐density lipoprotein sleeping sickness VSG
Urunga tuihono:	https://doi.org/10.1096/fba.2019-00033
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!