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Identification of Modulators of the <i>C.</i> <i>elegans</i> Aryl Hydrocarbon Receptor and Characterization of Transcriptomic and Metabolic AhR-1 Profiles

The Aryl hydrocarbon Receptor (AhR) is a xenobiotic sensor in vertebrates, regulating the metabolism of its own ligands. However, no ligand has been identified to date for any AhR in invertebrates. In <i>C.</i> <i>elegans</i>, the AhR ortholog, AHR-1, displays physiological functions. Therefore, we...

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Principais autores: Lucie Larigot, Linh-Chi Bui, Marine de Bouvier, Ophélie Pierre, Grégory Pinon, Justine Fiocca, Mohammad Ozeir, Cendrine Tourette, Chris Ottolenghi, Sandrine Imbeaud, Clément Pontoizeau, Benjamin J. Blaise, Aline Chevallier, Céline Tomkiewicz, Béatrice Legrand, Bénédicte Elena-Herrmann, Christian Néri, Vanessa Brinkmann, Pierre Nioche, Robert Barouki, Natascia Ventura, Julien Dairou, Xavier Coumoul
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-05-01
coleção:Antioxidants
Assuntos:
Aryl hydrocarbon Receptor
<i>Caenorhabditis elegans</i>
transcriptomics
metabolomics
modulators
Acesso em linha:https://www.mdpi.com/2076-3921/11/5/1030
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