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Combination of hypoxia and hyperosmolarity reduces in vitro chondrocyte de-differentiation

IntroductionArticular cartilage (AC) is an avascular tissue with a highly specialized extracellular matrix (ECM) microenvironment characterized by low oxygen tension and high osmolarity. Standard in vitro culture conditions fail to replicate these features and may promote chondrocyte de-differentiat...

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Principais autores: Elena De Angelis, Roberta Saleri, Filippo Marcotti, Luca Ferrari, Valeria Cavalli, Rosanna Di Lecce, Matteo Zoboli, Francesca Ravanetti, Benedetta Passeri, Paolo Martelli, Paolo Borghetti
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-03-01
Serier:Frontiers in Veterinary Science
Fag:
articular cartilage
chondrocytes
differentiation
hypoxia
osmolarity
Online adgang:https://www.frontiersin.org/articles/10.3389/fvets.2026.1802356/full
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