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Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif

Thioredoxin reductase (TXNRD) is a selenoprotein that plays a crucial role in cellular antioxidant defense. Previously, a distinctive guiding bar motif was identified in TXNRD1, which influences the transfer of electrons. In this study, utilizing single amino acid substitution and Excitation-Emissio...

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Autori principali: Wuyang Shi, Shibo Sun, Haowen Liu, Yao Meng, Kangshuai Ren, Guoying Wang, Minghui Liu, Jiaqi Wu, Yue Zhang, Huang Huang, Meiyun Shi, Weiping Xu, Qiang Ma, Bingbing Sun, Jianqiang Xu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2024-04-01
Serie:Redox Biology
Soggetti:
Thioredoxin reductase
Thioredoxin
Selenoprotein
Guiding bar motif
Caveolin-1
LCS3
Accesso online:http://www.sciencedirect.com/science/article/pii/S2213231724000260
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