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Neonatal overfeeding attenuates microgliosis and hippocampal damage in an infant rat model of pneumococcal meningitis

BackgroundPneumococcal meningitis (PM) triggers apoptotic neuronal and progenitor cell death in the hippocampal dentate gyrus (DG), resulting in subsequent cognitive impairment. Microglia play a crucial role in PM-induced hippocampal damage. While the lasting effects of neonatal nutrition on health...

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Principais autores: Larissa Marcely Gomes Cassiano, Karina Barbosa de Queiroz, Thais Veronez de Andrade Martins, Ana Luiza Azevedo Maia, Milene Alvarenga Rachid, Sarah J. Spencer, Roney Santos Coimbra
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-10-01
Serier:Frontiers in Immunology
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Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1429157/full
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