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VEGF controls microglial phagocytic response to amyloid-β

Microglial cells are well known to be implicated in the pathogenesis of Alzheimer’s disease (AD), due to the impaired clearance of amyloid-β (Aβ) protein. In AD, Aβ accumulates in the brain parenchyma as soluble oligomers and protofibrils, and its aggregation process further give rise to amyloid pla...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Priscille de Gea, Sarah Benkeder, Pauline Bouvet, Mélanie Aimard, Naura Chounlamountri, Jérôme Honnorat, Le Duy Do, Claire Meissirel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2023-12-01
Schriftenreihe:Frontiers in Cellular Neuroscience
Schlagworte:
microglia
Alzheimer’s disease
VEGF
amyloid-β
TREM2
phagocytosis
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fncel.2023.1264402/full
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