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Gene editing technology to improve antitumor T-cell functions in adoptive immunotherapy

Abstract Adoptive immunotherapy, in which tumor-reactive T cells are prepared in vitro for adoptive transfer to the patient, can induce an objective clinical response in specific types of cancer. In particular, chimeric antigen receptor (CAR)-redirected T-cell therapy has shown robust responses in h...

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Principais autores: Yusuke Ito, Satoshi Inoue, Yuki Kagoya
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-03-01
Serier:Inflammation and Regeneration
Fag:
Adoptive immunotherapy
Chimeric antigen receptor
Epigenetics
DNA methylation
PRDM1
Memory T cell
Online adgang:https://doi.org/10.1186/s41232-024-00324-7
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