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Alveolar epithelial barrier disruption by FKBP5-mediated necroptosis aggravates lung injury

Abstract Alveolar epithelial barrier damage is a key pathological feature of acute respiratory distress syndrome (ARDS). The glycocalyx and tight junctions are essential for maintaining epithelial barrier function, and their disruption exacerbates pulmonary edema. Although FK506-binding protein 51 (...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Jinfeng Cui, Wei Liu, Yue Zhou, Xinkai Qiu, Yangyang Xiao, Xiaozhi Wang, Tao Wang, Dong Zhang
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2026-04-01
Schriftenreihe:Respiratory Research
Schlagworte:
Alveolar epithelium
FKBP5
Necroptosis
Glycocalyx
Tight junctions
Online-Zugang:https://doi.org/10.1186/s12931-026-03696-1
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