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Genetic Ablation of Prorenin Receptor in the Rostral Ventrolateral Medulla Influences Blood Pressure and Hydromineral Balance in Deoxycorticosterone-Salt Hypertension

Abstract Non-enzymatic activation of renin via its interaction with prorenin receptor (PRR) has been proposed as a key mechanism of local renin–angiotensin system (RAS) activation. The presence of renin and angiotensinogen has been reported in the rostral ventrolateral medulla (RVLM). Overactivation...

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Autors principals: Natalia M Mathieu, Eva M Fekete, Patricia C Muskus, Daniel T Brozoski, Ko-Ting Lu, Kelsey K Wackman, Javier Gomez, Shi Fang, John J Reho, Connie C Grobe, Ibrahim Vazirabad, Gary C Mouradian, Matthew R Hodges, Jeffrey L Segar, Justin L Grobe, Curt D Sigmund, Pablo Nakagawa
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2023-01-01
Col·lecció:Function
Matèries:
hypertension
blood pressure
autonomic function
rostral ventrolateral medulla
prorenin receptor
Atp6ap2
Accés en línia:https://journals.physiology.org/doi/10.1093/function/zqad043
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