The Class I PI3K inhibitor S14161 induces autophagy in malignant blood cells by modulating the Beclin 1/Vps34 complex
S14161 is a pan-Class I PI3K inhibitor that induces blood cancer cell death, but its mechanism is largely unknown. In the present study, we evaluated the role of S14161 in autophagy, an emerging event in cell destination. Multiple myeloma cell lines RPMI-8226, OPM2, KMS11 and leukemia cell line K562...
Salvato in:
| Autori principali: | , , , , , , , , , |
|---|---|
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2017-08-01
|
| Serie: | Journal of Pharmacological Sciences |
| Soggetti: | |
| Accesso online: | http://www.sciencedirect.com/science/article/pii/S1347861317301007 |
| Tags: |
Nessun Tag, puoi essere il primo ad aggiungerne!!
|