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The effect of combining antibiotics on resistance: A systematic review and meta-analysis

Background: Under which conditions antibiotic combination therapy decelerates rather than accelerates resistance evolution is not well understood. We examined the effect of combining antibiotics on within-patient resistance development across various bacterial pathogens and antibiotics. Methods: We...

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Principais autores: Berit Siedentop, Viacheslav N Kachalov, Christopher Witzany, Matthias Egger, Roger D Kouyos, Sebastian Bonhoeffer
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2024-12-01
Serier:eLife
Fag:
antibiotic resistance
resistance evolution
combination therapy
meta-analysis
systematic review
Online adgang:https://elifesciences.org/articles/93740
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