A precision medicine approach to interpret a GATA4 genetic variant in a paediatric patient with congenital heart disease

Abstract Background Patients with congenital heart disease are identified in 1% of live births. Improved surgical intervention means many patients now survive to adulthood, the corollary of which is increased mortality in the over-65-year-old congenital heart disease (CHD) population. In the clinic,...

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Autors principals:	Catherine A. Forbes, Nicole C. Shaw, Kevin G. Chen, Mitchell Hedges, Teagan S. Er, Livia Hool, Michelle Ward, Cathryn Poulton, Gareth Baynam, Timo Lassmann, Vanessa S. Fear
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-01-01
Col·lecció:	Human Genomics
Matèries:	GATA4 Induced pluripotent stem cells CRISPR gene editing Cardiac disease modelling Congenital heart disease
Accés en línia:	https://doi.org/10.1186/s40246-025-00907-6
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