Mass cytometric analysis of the immune cell landscape after traumatic brain injury elucidates the role of complement and complement receptors in neurologic outcomes

Abstract Following traumatic brain injury (TBI), a neuroinflammatory response can persist for years and contribute to the development of chronic neurological manifestations. Complement plays a central role in post-TBI neuroinflammation, and C3 opsonins and the anaphylatoxins (C3a and C5a) have been...

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Bibliografische Detailangaben

Hauptverfasser:	Amer Toutonji, Carsten Krieg, Davis M. Borucki, Mamatha Mandava, Silvia Guglietta, Stephen Tomlinson
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2023-06-01
Schriftenreihe:	Acta Neuropathologica Communications
Schlagworte:	Traumatic brain injury Complement Neuroinflammation Complement inhibition Microglia Mass cytometry
Online-Zugang:	https://doi.org/10.1186/s40478-023-01583-0
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