Decoupling HIV-1 antiretroviral drug inhibition from plasma antibody activity to evaluate broadly neutralizing antibody therapeutics and vaccines

Summary: The development of broadly neutralizing antibody (bnAb)-based therapeutic HIV-1 vaccines and cure concepts depends on monitoring bnAb plasma activity in people with HIV (PWH) on suppressive antiretroviral therapy (ART). To enable this, analytical strategies must be defined to reliably disti...

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Bibliografische Detailangaben

Hauptverfasser:	Magdalena Schwarzmüller, Cristina Lozano, Merle Schanz, Irene A. Abela, Silvan Grosse-Holz, Selina Epp, Martina Curcio, Jule Greshake, Peter Rusert, Michael Huber, Roger D. Kouyos, Huldrych F. Günthard, Alexandra Trkola
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2024-09-01
Schriftenreihe:	Cell Reports Medicine
Schlagworte:	HIV-1 neutralizing antibody antiretroviral therapy
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2666379124004233
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