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Community-informed trial design and implementation to optimize recruitment and retention in low-income settings: lessons from rheumatic heart disease trials in Uganda

Research teams undertaking randomized clinical trials in low-and middle-income countries frequently encounter significant challenges, including limited infrastructure, cultural barriers to trust, and limited resources. Rheumatic heart disease (RHD) trials can be especially difficult because early st...

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Hoofdauteurs: Juliet Alepere, Susan Akullo, Pamela Okwir Apio, Brenda Atim, Andrea Beaton, Anneke Grobler, Samalie Kitooleko, Haddy Nalubwama, Emma Ndagire, Emmy Okello, Isaac Otim Omara, Jafes Pulle, Joselyn Rwebembera, Craig Sable, Amy Scheel, Alison Spaziani, Andrew Steer, Rachel Sarnacki
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2026-07-01
Reeks:Frontiers in Cardiovascular Medicine
Onderwerpen:
adherence
community
trial consent
engagement
low-resource
pediatric
Online toegang:https://www.frontiersin.org/articles/10.3389/fcvm.2026.1851733/full
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