Demethylzeylasteral induces PD-L1 ubiquitin–proteasome degradation and promotes antitumor immunity via targeting USP22

Programmed cell death ligand-1 (PD-L1) is a T cell inhibitory immune checkpoint molecule that interacts with programmed cell death-1 (PD-1) to promote immune escape of tumor cells. Compared with antibody therapies, small molecule drugs show better prospects due to their advantages such as higher bio...

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Autori principali:	Yanyan Zhang, Yun Huang, Dianping Yu, Mengting Xu, Hongmei Hu, Qing Zhang, Minchen Cai, Xiangxin Geng, Hongwei Zhang, Jianhua Xia, Mengmeng Guo, Dong Lu, Hanchi Xu, Linyang Li, Xing Zhang, Qun Wang, Sanhong Liu, Weidong Zhang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2024-10-01
Serie:	Acta Pharmaceutica Sinica B
Soggetti:	Demethylzeylasteral PD-L1 USP22 Deubiquitination Tumor-infiltrating lymphocytes Colorectal cancer
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2211383524003204
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