Fluoro-Aryl Substituted α,β2,3-Peptides in the Development of Foldameric Antiparallel β-Sheets: A Conformational Study

α,β2,3-Disteroisomeric foldamers of general formula Boc(S-Ala-β-2R,3R-Fpg)nOMe or Boc(S-Ala-β-2S,3S-Fpg)nOMe were prepared from both enantiomers of syn H-2-(2-F-Phe)-h-PheGly-OH (named β-Fpg) and S-alanine. Our peptides show two appealing features for biomedical applications: the presence of fluorin...

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Principais autores:	Raffaella Bucci, Alessandro Contini, Francesca Clerici, Egle Maria Beccalli, Fernando Formaggio, Irene Maffucci, Sara Pellegrino, Maria Luisa Gelmi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-04-01
coleção:	Frontiers in Chemistry
Assuntos:	β2,3-diaryl-amino acid α, β2,3-peptide extended peptide antiparallel β-sheet conformational analyses foldamers
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fchem.2019.00192/full
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